Mga baryante ng SARS-CoV-2

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Ang SARS-CoV-2 na nagsasanhi ng COVID-19 sa mundo sa kasalukuyan
Positive, negative, and neutral mutations during the evolution of coronaviruses like SARS-CoV-2.

Ang Mga baryante ng SARS-CoV-2 ay ang mga baryante ng SARS-CoV-2 na nagsanhi ng pandemya sa mundo bunsod ng COVID-19, bawat bansa ay nakitaan ng mutution mula sa mga strain ng SARS-CoV-2 na nag mula sa Wuhan, Hubei, Tsina noong Disyembre 1, 2019. Ang mga baryante ng SARS-CoV-2 ay ang mga sanga'ng anak dahil sa pag mutate ng birus, ang iba't ibang baryante ay mayroong kakayahang kumopya ng kawangis upang magparami, mayroong mga baryante ay nagkakamali ng pagkopya mula sa strain na ito o tinatawag na "error spelled". ito ay hindi na maaring magpakalat ng baryant.

Talahanayan ng Pangkalahatang ideya[baguhin | baguhin ang batayan]

Unang deteksyon PANGOLIN nomenclature Ibang pangalan Notable mutations Evidence of clinical changes[note 1] Pagkalat Sang.
 United Kingdom 2020 Pebrero[1] Global B.1.1.7 20I/501Y.V1 VOC-20DEC-01[A] N501Y, 69–70del, P681H[2][3] Padron:Estimate higher[4] Padron:Estimate more lethal[5][B] No change[7]
 Nigeria 2020 Agosto[8] Global B.1.1.207 P681H[2] No evidence of change[9] No evidence of change[9] Under investigation
 United States 2020 Hunyo[10] Global B.1.429, B.1.427[11] 20C/S:452R CAL.20C[12] I4205V, D1183Y, S13I, W152C, L452R Padron:Estimate (18.6%–24.2%) higher[13][14] Under investigation Moderate-to-severe reduction in neutralisation[15]
 South Africa 2020 Oktubre[2] Global B.1.351 20H/501Y.V2 VOC-20DEC-02 501Y.V2[7] N501Y, K417N, E484K[2] Padron:Estimate higher[7] No evidence of change[9] Significant reduction in neutralisation by antibodies[16][17]
 India 2020 Oktubre[18] Global B.1.617 VUI-21APR-01[19] E484Q, L452R, P681R[20] Under investigation Under investigation Slight reduction in effective neutralisation[21]
 Japan
 Brazil
2020 Disyembre[22] Global P.1 20J/501Y.V3 VOC-21JAN-02 B.1.1.28.1[23][11] N501Y, E484K, K417T[2] Padron:Estimate higher[24][C]Padron:Better source needed Padron:Estimate more lethal[25][D] Overall reduction in effective neutralisation[7]
 United Kingdom
 Nigeria
2020 Disyembre[26] Global B.1.525 20C[E] VUI-21FEB-03[F] E484K, F888L[27] Under investigation Under investigation Possibly reduced neutralisation[13]
  1. B.1.1.7 with E484K is separately designated VOC-21FEB-02
  2. Another study[6] has estimated that B.1.1.7 may be 32–104% more lethal
  3. Another preliminary study[25] has estimated that P.1 may be 170–240% more transmissible, with a credible interval with a low probability of 50%.
  4. The reported credible interval has a low probability of only 50%, so the estimated lethality can only be understood as possible, not certain nor likely.
  5. Includes B.1.525 and B.1.526.[13]
  6. Formerly UK1188.

Kilalang baryante[baguhin | baguhin ang batayan]

Taon WHO lebel Baryante Pamagat Pinagmulan
1. 2019 2019-nCoV c SARSr-CoV Republikang Bayan ng Tsina Pandemya ng COVID-19 (COVID-19) Wuhan, Tsina
2. 2020 Alpha A SARS-CoV-2 Alpha variant (aktibo) Pagkalat ng B.1.1.7 ng 2020 (COVID-19) Kent, United Kingdom
3. 2020 Beta B SARS-CoV-2 Beta variant (aktibo) Pagkalat ng 501.V2 (COVID-19) Silangang Cape, Timog Aprika
4. 2021 Gamma Γ SARS-CoV-2 Gamma variant Pagkalat ng Lineage P.1 (COVID-19) Manaus, Brazil
5. 2021 Delta Δ SARS-CoV-2 Delta variant (aktibo) Pagkalat ng B.1.617.2 (COVID-19) New Delhi, India
6. 2021 Delta δ SARS-CoV-2 Delta Plus variant (aktibo) Pagkalat ng B.1.617.2 (COVID-19) Nepal & Maharashtra, India
7. 2020 Epsilon ε SARS-CoV-2 Epsilon variant Pagkalat ng CAL.20C (COVID-19) Los Angeles, California, USA
8. 2021 Zeta ζ SARS-CoV-2 Zeta variant Pagkalat ng Lineage P.2 (COVID-19) Rio de Janeiro, Brazil
9. 2020 Eta η SARS-CoV-2 Eta variant Pagkalat ng Lineage B.1.525 (COVID-19) Lagos, Nigeria
10. 2020 -- Lineage B.1.1.207 Pagkalat ng Lineage B.1.1.207 (COVID-19) Nigeria
11. 2020 -- SARS-CoV-2 Cluster 5 variant Pagkalat ng Cluster 5 (COVID-19) Hilagang Jutland, Denmark
12. 2021 B.1.1.7 w/ E484K Lineage B.1.1.318 Pagkalat ng B.1.1.318 (COVID-19) United Kingdom
13. 2021 Theta Θ SARS-CoV-2 Theta variant Pagkalat ng Lineage P.3 (COVID-19) Cebu, Pilipinas
14. 2020 Iota ι SARS-CoV-2 Iota variant (aktibo) Pagkalat ng B.1.526 (COVID-19) Lungsod ng Bagong York
15. 2021 Kappa κ SARS-CoV-2 Kappa variant Pagkalat ng Lineage B.1.617 (COVID-19) Delhi, India
16. 2021 Lambda Λ SARS-CoV-2 Lambda variant (aktibo) Pagkalat ng Lineage C.37 (COVID-19) Lima, Peru
17. 2021 Mu μ SARS-CoV-2 Mu variant (aktibo) Pagkalat ng Lineage B.1.621 (COVID-19) Colombia

Mga iba't ibang pag-aalala (WHO)[baguhin | baguhin ang batayan]

  • Alpha (lineage B.1.1.7), B.1.1.7 kabilang ang E484K
  • Delta (lineage B.1.617.2)
  • Beta (lineage B.1.351)
  • Gamma (lineage P.1)

Mga iba't ibang interes (WHO)[baguhin | baguhin ang batayan]

  • Eta (lineage B.1.525)
  • Iota (lineage B.1.526)
  • Kappa (lineage B.1.617.1)
  • Lambda (lineage C.37)
  • Mu (lineage B.1.621)

Mga dating iba't ibang interes (WHO)[baguhin | baguhin ang batayan]

  • Epsilon (lineages B.1.429, B.1.427, CAL.20C)
  • Zeta (lineage P.2)
  • Theta (lineage P.3)

Mga ibang kilalang baryant[baguhin | baguhin ang batayan]

R.1
Lineage B.1.1.207
Lineage B.1.620
Dinagdag na baryante
  • Lineage B.1.618
  • Lineage B.1.1.318
  • Lineage B.1.1.317

Kilalang mutasyon[baguhin | baguhin ang batayan]

N440K
L452R
S477G/N
E484Q
E484K
N501Y
D614G
P681H
P681R
A701V

Tingnan rin[baguhin | baguhin ang batayan]

Sanggunian[baguhin | baguhin ang batayan]

  1. Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang pango-lineages); $2
  2. 2.0 2.1 2.2 2.3 2.4 Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang :3); $2
  3. Chand et al. (2020), p. 6, Potential impact of spike variant N501Y.
  4. Padron:Cite techreport
  5. Davies G, Jarvis C, Edmunds WJ, Jewell N, Diaz-Ordaz K, Keogh R (2021-03-15). "Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7" (Published). doi:10.1038/s41586-021-03426-1. Nakuha noong 2021-04-29 – sa pamamagitan ng/ni Nature. Cite journal requires |journal= (tulong)
  6. DChallen R, Brooks-Pollock E, Read J, Dyson L, Tsaneva-Atanasova K, Danon L (2021-03-10). "Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study" (Published). doi:10.1136/bmj.n579. Nakuha noong 2021-04-29 – sa pamamagitan ng/ni The BMJ. Cite journal requires |journal= (tulong)
  7. 7.0 7.1 7.2 7.3 Padron:Cite techreport
  8. "Lineage B.1.1.207". cov-lineages.org. Pango team. Nakuha noong 2021-03-11. Graphic shows B.1.1.207 detected in Peru, Germany, Singapore, Hong Kong, Vietnam, Costa Rica, South Korea, Canada, Australia, Japan, France, Italy, Ecuador, Mexico, UK and the USA.
  9. 9.0 9.1 9.2 Sruthi S (2021-02-10). "Notable Variants And Mutation Of SARS-CoV-2". BioTecNika. Nakuha noong 2021-03-22.
  10. "Lineage B.1.429". cov-lineages.org. Pango team. Nakuha noong 2021-03-19. Graphic shows B.1.429 detected in the USA, Mexico, Canada, the UK, France, Denmark, Australia, Taiwan, Japan, South Korea, Australia, New Zealand, Guadeloupe, and Aruba.
  11. 11.0 11.1 Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang aci-variants); $2
  12. "Southern California COVID-19 Strain Rapidly Expands Global Reach". Cedars-Sinai Newsroom. Los Angeles. 2021-02-11. Nakuha noong 2021-03-17.
  13. 13.0 13.1 13.2 Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang cdc-variants); $2
  14. Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, atbp. (March 2021). "Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation". medRxiv (Preprint). doi:10.1101/2021.03.07.21252647. PMC 7987058. PMID 33758899 Check |pmid= value (tulong).
  15. Wadman M (2021-02-23). "California coronavirus strain may be more infectious - and lethal". Science News. doi:10.1126/science.abh2101. Nakuha noong 2021-03-17.
  16. Planas D, Bruel T, Grzelak L, atbp. (2021-04-14). "Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies". Nature Medicine. doi:10.1038/s41591-021-01318-5.
  17. "Coronavirus: Sinovac vaccine gives 70 per cent less protection against South African variant, but Hongkongers urged to still get jab". www.scmp.com. 20 April 2021. Nakuha noong 20 April 2021.
  18. "PANGO lineages". cov-lineages.org. Nakuha noong 2021-04-17.
  19. Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang IndiaPHE); $2
  20. Nuki, Paul; Newey, Sarah (2021-04-16). "Arrival of India's 'double mutation' adds to variant woes, but threat posed remains unclear". The Telegraph (sa wikang Ingles). ISSN 0307-1235. Nakuha noong 2021-04-17.
  21. Yadav PD, Sapkal GN, Abraham P, Ella R, Deshpande G, Patil DY, atbp. (April 2021). "Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees". medRxiv (Preprint). doi:10.1101/2021.04.23.441101.
  22. Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang ImmuneEscape); $2
  23. "P.1". cov-lineages.org. Pango team. Nakuha noong 2021-03-22.
  24. Coutinho RM, Marquitti FM, Ferreira LS, Borges ME, da Silva RL, Canton O, atbp. (2021-03-23). "Model-based estimation of transmissibility and reinfection of SARS-CoV-2 P.1 variant". medRxiv (Preprint): 9. doi:10.1101/2021.03.03.21252706. Nakuha noong 2021-04-29. The new variant was found to be about 2.6 times more transmissible (95% Confidence Interval (CI): 2.4–2.8) than previous circulating variant(s). ... Table 1: Summary of the fitted parameters and respective confidence intervals considering the entire period, November 1 2020-January 31, 2021 maintaining the same pathogenicity of the previous variant. Parameter: Relative transmission rate for the new variant. Estimate: 2.61. 2.5%: 2.45. 97.5%: 2.76.
  25. 25.0 25.1 Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang cadde-p1); $2
  26. Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang UK); $2
  27. Maling banggit (Hindi tamang <ref> tag; walang binigay na teksto para sa refs na may pangalang Pango B.1.525); $2


Maling banggit (May <ref> tag na ang grupong "note", pero walang nakitang <references group="note"/> tag para rito); $2