Tingnan ang wikitext ng Abacavir

{{Infobox drug|Watchedfields=changed|verifiedrevid=477236809|image=Abacavir.svg|width=200|alt=|image2=Abacavir ball-and-stick model.png|alt2=|caption=Istrukturang kemikal ng abacavir|pronounce={{IPAc-en|audio=en-abacavir.ogg|ə|ˈ|b|æ|k|ə|v|ɪər}}|tradename=Ziagen|Drugs.com={{drugs.com|monograph|abacavir}}|MedlinePlus=a699012|licence_EU=yes|DailyMedID=Abacavir|pregnancy_AU=B3|pregnancy_AU_comment=|pregnancy_category=|routes_of_administration=[[Oral administration|Gamit ang bibig]]|class=|ATC_prefix=J05|ATC_suffix=AF06|ATC_supplemental=<!-- Legal status -->|legal_AU=S4|legal_AU_comment=<ref>{{Cite web |url=http://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2011-PI-01963-3 |title=TGA eBS - Product and Consumer Medicine Information Licence |access-date=23 August 2022 |archive-date=24 March 2022 |archive-url=https://web.archive.org/web/20220324155412/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2011-PI-01963-3 |url-status=live }}</ref>|legal_CA=<!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->|legal_CA_comment=|legal_DE=<!-- Anlage I, II, III or Unscheduled -->|legal_DE_comment=|legal_NZ=<!-- Class A, B, C -->|legal_NZ_comment=|legal_UK=POM|legal_UK_comment=|legal_US=Rx-only|legal_US_comment=<ref name="Ziagen FDA label" />|legal_EU=Rx-only|legal_EU_comment=<ref name="Ziagen EPAR">{{cite web | title=Ziagen EPAR | website=European Medicines Agency | date=17 September 2018 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/ziagen | access-date=22 August 2022 | archive-date=30 July 2022 | archive-url=https://web.archive.org/web/20220730022026/https://www.ema.europa.eu/en/medicines/human/EPAR/ziagen | url-status=live }} Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</ref>|legal_UN=<!-- N I, II, III, IV / P I, II, III, IV -->|legal_UN_comment=|legal_status=<!-- For countries not listed above -->

<!-- Pharmacokinetic data -->|bioavailability=83%|protein_bound=|metabolism=[[Liver]]|metabolites=|onset=|elimination_half-life=1.54 ± 0.63 h|duration_of_action=|excretion=[[Kidney]] (1.2% abacavir, 30% 5'-carboxylic acid metabolite, 36% 5'-glucuronide metabolite, 15% unidentified minor metabolites). Fecal (16%)

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Ang '''Abacavir''', na ibinebenta sa ilalim ng tatak na '''Ziagen''' bukod sa iba pa, ay isang gamot na ginagamit sa panggagamot sa [[HIV/AIDS]]. <ref name="Ziagen FDA label">{{Cite web |date=30 September 2015 |title=Ziagen- abacavir sulfate tablet, film coated label |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ca73b519-015a-436d-aa3c-af53492825a1 |url-status=live |archive-url=https://web.archive.org/web/20170111183846/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ca73b519-015a-436d-aa3c-af53492825a1 |archive-date=2017-01-11 |access-date=2019-09-09 |publisher=[[DailyMed]]}}</ref><ref name="AHFS2015">{{Cite web |title=Abacavir Sulfate |url=https://www.drugs.com/monograph/abacavir-sulfate.html |url-status=live |archive-url=https://web.archive.org/web/20170821211053/https://www.drugs.com/monograph/abacavir-sulfate.html |archive-date=21 August 2017 |access-date=31 July 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> <ref>{{Cite web |title=Drug Name Abbreviations Adult and Adolescent ARV Guidelines |url=https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/292/drug-name-abbreviations |url-status=live |archive-url=https://web.archive.org/web/20161109083720/https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/292/drug-name-abbreviations |archive-date=2016-11-09 |access-date=2016-11-08 |website=AIDSinfo}}</ref> Katulad ng iba pang ng mga nucleoside analog na mga reverse-transcriptase inhibitors (NRTIs), ang abacavir ay ginagamit kasama ng iba pang mga gamot sa HIV, at hindi ito inirerekomenda nang mag-isa lamang. <ref>{{Cite web |title=What Not to Use Adult and Adolescent ARV Guidelines |url=https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/12/what-not-to-use |url-status=live |archive-url=https://web.archive.org/web/20161109021833/https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/12/what-not-to-use |archive-date=2016-11-09 |access-date=2016-11-08 |website=AIDSinfo}}</ref> Ito ay kinukuha sa pamamagitan ng bibig bilang isang tableta o solusyon at maaaring gamitin sa mga batang edad higit sa tatlong buwan. <ref name="AHFS2015" /> <ref name="Yu2008">{{Cite journal |vauthors=Yuen GJ, Weller S, Pakes GE |date=2008 |title=A review of the pharmacokinetics of abacavir |journal=Clinical Pharmacokinetics |volume=47 |issue=6 |pages=351–371 |doi=10.2165/00003088-200847060-00001 |pmid=18479171}}</ref>

Ang Abacavir sa pangkalahatan ay mahusay na disimulado. <ref name="Yu2008" /> Kasama sa mga karaniwang ''side effect'' o resulta ng pagkonsumo ang pagsusuka, hindi nakakatulog (problema sa pagtulog), lagnat, at pakiramdam ng pagod. <ref name="AHFS2015">{{Cite web |title=Abacavir Sulfate |url=https://www.drugs.com/monograph/abacavir-sulfate.html |url-status=live |archive-url=https://web.archive.org/web/20170821211053/https://www.drugs.com/monograph/abacavir-sulfate.html |archive-date=21 August 2017 |access-date=31 July 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> Kabilang sa iba pang karaniwang resulta ng pagkonsumo ang pagkawala ng gana, pananakit ng ulo, pagduduwal (pakiramdam ng sakit), pagtatae, pantal, at pagkahilo (kawalan ng enerhiya).  Ang mas matinding epekto ay kinabibilangan ng hipersensitibilidad, pinsala sa atay, at lactic acidosis . <ref name="AHFS2015" /> Maaaring ipahiwatig ng pagsusuring henetiko kung ang isang tao ay nasa mas mataas na panganib na magkaroon ng hipersensitibilidad. <ref name="AHFS2015" /> Ang mga sintomas ng hipersensitibilidad ay kinabibilangan ng pantal, pagsusuka, at kakapusan sa paghinga. <ref name="Yu2008">{{Cite journal |vauthors=Yuen GJ, Weller S, Pakes GE |date=2008 |title=A review of the pharmacokinetics of abacavir |journal=Clinical Pharmacokinetics |volume=47 |issue=6 |pages=351–371 |doi=10.2165/00003088-200847060-00001 |pmid=18479171}}</ref> Ang Abacavir ay nasa klase ng NRTI na mga gamot, na gumagana sa pamamagitan ng pagharang sa reverse transcriptase, isang ensima na kailangan para sa replikasyon ng HIV na birus . <ref name="Gov2016">{{Cite web |title=Nucleoside reverse transcriptase inhibitors (NRTIs or 'nukes') - HIV/AIDS |url=http://www.hiv.va.gov/patient/treat/NRTIs.asp |url-status=live |archive-url=https://web.archive.org/web/20161109083725/http://www.hiv.va.gov/patient/treat/NRTIs.asp |archive-date=2016-11-09 |access-date=2016-11-08 |website=www.hiv.va.gov}}</ref> Sa loob ng klase ng NRTI, ang abacavir ay isang carbocyclic nucleoside . <ref name="AHFS2015" />

Ang Abacavir ay na-patent noong 1988. Ito rin ay inaprubahan para gamitin sa Estados Unidos noong 1998. <ref>{{Cite book |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA505 |title=Analogue-based Drug Discovery |vauthors=Fischer J, Ganellin CR |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=505 |archive-url=https://web.archive.org/web/20170908213935/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA505 |archive-date=2017-09-08 |url-status=live |df=dmy-all}}</ref> <ref>{{Cite book |url=https://books.google.com/books?id=RFNVvStUJlkC&pg=PA56 |title=HIV/AIDS Treatment Drugs |vauthors=Kane BM |date=2008 |publisher=Infobase Publishing |isbn=9781438102078 |page=56 |archive-url=https://web.archive.org/web/20170908213935/https://books.google.com/books?id=RFNVvStUJlkC&pg=PA56 |archive-date=2017-09-08 |url-status=live |df=dmy-all}}</ref> Ito ay nasa Listahan ng mga Mahahalagang Gamot ng World Health Organization . <ref name="WHO21st">{{Cite book |author-link=World Health Organization |title=World Health Organization model list of essential medicines: 21st list 2019 |vauthors=((World Health Organization)) |publisher=World Health Organization |year=2019 |location=Geneva |hdl=10665/325771 |id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO |hdl-access=free}}</ref> Ito ay magagamit bilang isang henerikong gamot . <ref name="AHFS2015">{{Cite web |title=Abacavir Sulfate |url=https://www.drugs.com/monograph/abacavir-sulfate.html |url-status=live |archive-url=https://web.archive.org/web/20170821211053/https://www.drugs.com/monograph/abacavir-sulfate.html |archive-date=21 August 2017 |access-date=31 July 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> Ang abacavir ay ginagamit kasama ng iba pang mga gamot sa HIV, tulad ng abacavir/lamivudine/zidovudine, abacavir/dolutegravir/lamivudine, at abacavir/lamivudine . <ref name="Yu2008">{{Cite journal |vauthors=Yuen GJ, Weller S, Pakes GE |date=2008 |title=A review of the pharmacokinetics of abacavir |journal=Clinical Pharmacokinetics |volume=47 |issue=6 |pages=351–371 |doi=10.2165/00003088-200847060-00001 |pmid=18479171}}</ref> <ref name="Gov2016">{{Cite web |title=Nucleoside reverse transcriptase inhibitors (NRTIs or 'nukes') - HIV/AIDS |url=http://www.hiv.va.gov/patient/treat/NRTIs.asp |url-status=live |archive-url=https://web.archive.org/web/20161109083725/http://www.hiv.va.gov/patient/treat/NRTIs.asp |archive-date=2016-11-09 |access-date=2016-11-08 |website=www.hiv.va.gov}}</ref> Ang kumbinasyong abacavir/lamivudine ay isang esensyal na gamot. <ref name="WHO21st" />

==Mga sanggunian==
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[[Kategorya:HIV/AIDS]]