Metabolismo ng droga

Ang metabolismo ng droga ay isang metabolikong pagkonsumo ng droga ng isang nabubuhay na organismo, na kadalasang dumadaan sa mga sistemang ensimatiko.^[1] Sa pangkalahatan, ang metabolismong xenobiyotiko (mula sa salitang Griyego xenos "hindi kilala" at biyotiko "na may kaugnayan sa nabubuhay") ay isang set ng daanang metaboliko na nagbabago sa kemikal na estruktura ng mga xenobiyotiko na kung saan ito ang mga kompuwesto na kakaiba sa normal na biyokemikal ng organismo tulad na lamang ng mga droga o lason.^[2] Isang anyo ng biotransformation ang mga daanang ito na makikita sa lahat ng pangkalahatang pangkat ng mga organismo, at kinokonsidera na galing pa makalumang panahon. Kadalasang kumikilos ang mga reaksyong ito upang mawala ang kompuwestong nakakalason.^[3] Ang pagaaral ng metabolismo ng droga ay ang parmakokinetiko.

Talababa

↑ Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (Setyembre 2003). "Impact of drug transporter studies on drug discovery and development". Pharmacol. Rev. 55 (3): 425–61. doi:10.1124/pr.55.3.1. PMID 12869659.{{cite journal}}: CS1 maint: date auto-translated (link)
↑ Thornalley PJ (Hulyo 1990). "The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life". Biochem. J. 269 (1): 1–11. PMC 1131522. PMID 2198020.{{cite journal}}: CS1 maint: date auto-translated (link)
↑ Guengerich FP (Hunyo 2001). "Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity". Chem. Res. Toxicol. 14 (6): 611–50. doi:10.1021/tx0002583. PMID 11409933.{{cite journal}}: CS1 maint: date auto-translated (link)

Malayuang pagbabasa

Parvez H, Reiss C (2001). Molecular Responses to Xenobiotics. Elsevier. ISBN 0-345-42277-5.{{cite book}}: CS1 maint: date auto-translated (link)
Ioannides C (2001). Enzyme Systems That Metabolise Drugs and Other Xenobiotics. John Wiley and Sons. ISBN 0-471-89466-4.{{cite book}}: CS1 maint: date auto-translated (link)
Richardson M (1996). Environmental Xenobiotics. Taylor & Francis Ltd. ISBN 0-7484-0399-X.{{cite book}}: CS1 maint: date auto-translated (link)
Ioannides C (1996). Cytochromes P450: Metabolic and Toxicological Aspects. CRC Press Inc. ISBN 0-8493-9224-1.{{cite book}}: CS1 maint: date auto-translated (link)
Awasthi YC (2006). Toxicology of Glutathionine S-transferses. CRC Press Inc. ISBN 0-8493-2983-3.{{cite book}}: CS1 maint: date auto-translated (link)

Mga kawing panlabas

Databases
- Drug metabolism database
- Directory of P450-containing Systems Naka-arkibo 2016-07-16 sa Wayback Machine.
- University of Minnesota Biocatalysis/Biodegradation Database
- SPORCalc Naka-arkibo 2009-03-18 sa Wayback Machine.
Metabolismo ng droga
- Small Molecule Drug Metabolism
- Drug metabolism portal
Microbial biodegradation
- Microbial Biodegradation, Bioremediation and Biotransformation

[pmid12869659-1] Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (Setyembre 2003). "Impact of drug transporter studies on drug discovery and development". Pharmacol. Rev. 55 (3): 425–61. doi:10.1124/pr.55.3.1. PMID 12869659.{{cite journal}}: CS1 maint: date auto-translated (link)

[pmid2198020-2] Thornalley PJ (Hulyo 1990). "The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life". Biochem. J. 269 (1): 1–11. PMC 1131522. PMID 2198020.{{cite journal}}: CS1 maint: date auto-translated (link)

[pmid11409933-3] Guengerich FP (Hunyo 2001). "Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity". Chem. Res. Toxicol. 14 (6): 611–50. doi:10.1021/tx0002583. PMID 11409933.{{cite journal}}: CS1 maint: date auto-translated (link)

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