Reseptor na 5-HT

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Ang mga reseptor na 5-HT (sa Ingles ay 5-hydroxytryptamine receptors o 5-HT receptors o serotonin receptors) ang pangkat ng mga pinagdugtong ng G protina na mga reseptor(G protein-coupled receptor o GPCR) at binabakuran-ng-ligandong kanelo ng ion(ligand-gated ion channels o LGIC) na matatagpuan sa sentral at periperal na sistemang nerbiyos. Ang mga ito ay tagapamagitan ng parehong nagpapanabik(excitatory) at nagpipigil(inhibitory) na neurotransmisyon. Ang mga reseptor na 5-HT ay pinapagana ng serotoninn na umaasal bilang mga natural na ligando ng mga ito.

Ang mga reseptor na 5-HT ay nangangasiwa sa paglabas ng maraming mga neurotransmitter gaya ng glutamate, GABA, dopamino(dopamine), epineprino(epinephrine) /norepineprino(norepinephrine), acetylcholine gayundin ang maraming mga hormone kabilang ang oxytocin, prolactin, vasopressin, cortisol, corticotropin at substansiyang P bukod sa iba pa. Ang mga reseptor na 5-HT ay umiimpluwensiya sa iba't ibang mga prosesong biolohikal at neurolohikal gaya ng agresyon, pagkabalisa(anxiety), gana(appetite), kognisyon, pagkatuto, memorya, damdamin(mood), nausea, pagtulog at termoregulasyon. Ang mga reseptor na 5-HT ang inaasinta(target) ng iba't ibang mga parmasyutikal at mga ilegal na droga kabilang ang antidepressant, antisikotiko, anorektiko, antiemetiko, mga ahenteng gastroprokinetiko, mga ahenteng nagpapalis ng migraine, halusiheniko, at entaktoheno. Ang mga drogang ito ay tinatawag na agonista.

Sa kabaligtaran, ang mga droga namang humaharang sa pagpapagana ng mga reseptor na 5-HT ay tinatawag na mga antagonista

Mga pamilya ng reseptor na 5-HT[i-edit | i-edit ang source]

Pamilya Uri Mekanismo Potensiyal
5-HT1 pinagdugtong ng protinang-Gi/Go. Nagbabawas ng lebel sa selula ng cAMP. Nagpipigil
5-HT2 pinagdugtong ng protinang-Gq/G11. Nagdadagdag ng lebel sa selula ng IP3 and DAG. Nagpapanabik
5-HT3 Binabakuran ng ligandong Na+ at K+ na kanelong kasyon. Nagsasagawa ng depolarisasyon sa membrano ng plasma. Nagpapanabik
5-HT4 pinagdugtong ng protinang-Gs. Nagdadagdag ng lebel sa selula ng cAMP. Nagpapanabik
5-HT5 pinagdugtong ng protinang-Gi/Go.[1] Nagbabawas ng lebel sa selula ng cAMP. Nagpipigil
5-HT6 pinagdugtong ng protinang-Gs. Nagdadagdag ng lebel sa selula ng cAMP. Nagpapanabik
5-HT7 pinagdugtong ng protinang-Gs. Nagdadagdag ng lebel sa selula ng cAMP. Nagpapanabik

Mga pang-ilalim na uri[i-edit | i-edit ang source]

Sa loob ng mga pangkalahatang klaseng ito ng mga reseptor na 5-HT, ang ilang mga spesipikong uri ay pinangkat ayon sa katangian ng mga ito: [2][3][4]

Buod ng mga reseptor na 5-HT
Reseptor Gene Distribusyon Tungkulin Agonista Antagonista
5-HT1A
5-HT1B
  • Blood Vessels
  • CNS
5-HT1D
  • Pagkabalisa(Anxiety)[35][36]
  • Lokomosyon[34]
  • Basokonstriksiyon
5-HT1e putative receptor
5-HT1F
  • CNS
  • Migraine
  • LY334370
  • COL-144
5-HT2A
  • Besel ng dugo
  • CNS
  • GI Tract
  • Platelet
  • PNS
  • Makinis na masel
  • Adiksiyon (potentially modulating) [37]
  • Pagkabalisa(Anxiety)[38]
  • Gana(Appetite)
  • Kognisyon
  • Imahinasyon
  • Pagkatuto
  • Memorya
  • Damdamin(Mood)
  • Persepsiyon
  • Pag-aasal na sekswal[39]
  • Tulog[40]
  • Termoregulasyon[41]
  • Vasoconstriction[42]
5-HT2B
  • Besel ng dugo
  • CNS
  • GI Tract
  • Platelets
  • PNS
  • Makinis na masel
  • Pagkabalisa(Anxiety)[43][44][45]
  • Gana(Appetite)[46]
  • Mga tungkuling kardiyobaskular
  • Motilidad na gastrointestinal[47]
  • Tulog[40]
  • Basokonstriksiyon
5-HT2C
  • Besel ng dugo
  • CNS
  • GI Tract
  • Platelet
  • PNS
  • Makinis na masel
  • Adiksiyon(Addiction). (potentially modulating)[37]
  • Pagkabalisa(Anxiety)[48][49][50]
  • Gana(Appetite)
  • Motilidad na gastrointestinal [51]
  • Lokomosyon
  • Damdamin(Mood)[49][50]
  • Ereksiyon ng titi(Penile Erection)[52][53]
  • Pag-aasal na sekswal[39]
  • Tulog[54]
  • Termoregulasyon[41]
  • Basokonstriksiyon
5-HT3
  • CNS
  • GI Tract
  • PNS
  • Adiksiyon
  • Pagkabalisa(Anxiety)
  • Emesis
  • Motilidad na gastrointestinal
  • Pagkatuto[56]
  • Memorya[56]
  • Nausea
5-HT4
  • CNS
  • GI Tract
  • PNS
5-HT5A
  • CNS
5-HT6
  • CNS
5-HT7
  • Besel ng dugo
  • CNS
  • GI Tract

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